Milk thistle has been used for a number of purposes including treatment of liver disease, prevention and treatment of cancer, and supportive treatment of poisoning from death cap mushrooms; however, clinical study results were described as heterogeneous and contradictory.  A 2007 Cochrane Review included eighteen randomized clinical trials which assessed milk thistle in 1088 patients with alcoholic and/or hepatitis B or C virus liver diseases. It questioned the beneficial effects and highlighted the lack of high-quality evidence. The review concluded that more good-quality, randomized clinical trials are needed.  Cancer Research UK say that milk thistle is promoted on the internet for its claimed ability to slow certain kinds of cancer, but that there is no good evidence in support of these claims.  Milk thistle may appear to stimulate prolactin due to possibly estrogenic activity.