As with all anabolic steroids Oxandrolone will suppress natural testosterone production in men. Testosterone suppression does vary from steroid to steroid in terms of the rate and Oxandrolone is one of the milder forms. However, most all men will still need some form of exogenous testosterone if they are using Oxandrolone at any significant dose for any significant time. Those who do not supplement with testosterone have an excellent chance of putting themselves into a low testosterone condition. For the purpose of information a performance level dosing of Oxandrolone will suppress natural testosterone production in most men by dropping serum testosterone levels by 50%. This will put most men into a low level state and if not certainly in a below optimal state.
Once the use of Oxandrolone is done and it along with all anabolic steroids has cleared the body natural testosterone production will begin again. It’s important to note that recovering prior natural levels assumes no prior low level condition existed and that there was no damage done to the HPTA during steroid use . Most men will need a Post Cycle Therapy (PCT) plan to aid in recovery, but they should also note that PCT will not promote full recovery. It takes several months to recover from anabolic steroid use and there’s no guarantee that you always will even with the best PCT plan in the world.
Testosterone can be administered parenterally , but it has more irregular prolonged absorption time and greater activity in muscle in enanthate , undecanoate , or cypionate ester form. These derivatives are hydrolyzed to release free testosterone at the site of injection; absorption rate (and thus injection schedule) varies among different esters, but medical injections are normally done anywhere between semi-weekly to once every 12 weeks. A more frequent schedule may be desirable in order to maintain a more constant level of hormone in the system.  Injectable steroids are typically administered into the muscle, not into the vein, to avoid sudden changes in the amount of the drug in the bloodstream. In addition, because estered testosterone is dissolved in oil, intravenous injection has the potential to cause a dangerous embolism (clot) in the bloodstream.
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