Oxandrolone in bodybuilding

In addition to the endogenous steroid metabolites highlighted in Figure 15-1 , there are also a variety of drugs with androgenic activity. These include anabolic steroids, such as nonaromatizable oxandrolone , that bind and activate AR (albeit with lower affinity than testosterone [ 43 ]) and a class of drugs under extensive development referred to as selective AR modulators (SARMs), which demonstrate tissue-specific agonist or antagonist activities with respect to AR transactivation [ 44 ]. These orally active nonsteroidal, nonaromatizable SARMS are being developed to target androgen action in bone, muscle, and fat and to influence libido but to not exacerbate prostate growth, hirsutism, and acne. Several have been identified with beneficial effects on bone mass [ 45–47 ] and provide a new alternative to androgen replacement therapy.

Oxandrolone in bodybuilding

oxandrolone in bodybuilding

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