Of concern to any user of Winstrol during a cycle should be its intoxicating effect on the liver . The drug is a 17aa structured steroid , meaning it has been structured in a way which allows it to be orally bio-available, yet this has the negative effect of making Winstrol potentially harmful to the liver. It is therefore paramount the duration of a Winstrol cycle is limited, the dose of the drug is not excessive, the user does not stack it with other hepatotoxic compounds, does not drink alcohol whilst on cycle, and does not use Winstrol if they have an underlying medical condition which effects the livers health. There are supplements available which also help protect the liver (Milk Thistle, Liv-52 etc), and these would be advisable during any Winstrol cycle .
The most common daily dose of Anapolon is 100mg, but even at that dosage side-effects like water-retention, elevated blood pressure, acne, hair loss, blood clotting changes, gynocomastia, liver toxicity and mood swings are very often reported. Using aromatase inhibitors to control estrogen aromatization will be ineffective as this drug does not directly convert into estrogen. It was suggested that oxymetholone can activate the estrogen receptor, similar to, but more profoundly than the estrogenic androgen methandriol. Supplements like Milk Thistle can be taken to help keep liver enzyme levels between safe ranges.